Kefsepim - awọn ilana osise fun lilo

Awọn itọkasi fun lilo oogun naa Kefsepim ni:
- pneumonia (iwọn-ara ati àìdá) ti o fa nipasẹ Streptococcus pneumoniae (pẹlu awọn ọran ti ajọṣepọ pẹlu bacteremia concomitant), Pseudomonas aeruginosa, Klebsiella pneumoniae tabi Enterobacter spp.
- awọn iṣan ito (mejeeji ti o nira ati laisi awọn ilolu),
- awọn arun ti awọ-ara ati awọn asọ asọ,
- awọn inira inu inu (ni apapọ pẹlu metronidazole) ti a fa nipasẹ Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter spp.,
- awọn ilana àkóràn ti dagbasoke lodi si abẹlẹ ti ipinlẹ ajẹsara (fun apẹẹrẹ, febrile neutropenia),
- idena ti awọn akoran lakoko iṣẹ-abẹ inu,

Awọn ipa ẹgbẹ

Lati inu ounjẹ ti ngbe ounjẹ: gbuuru, inu riru, eebi, àìrígbẹyà, irora inu, dyspepsia,
Eto inu ọkan ati ẹjẹ: irora lẹhin ẹhin, tachycardia,
Awọn apọju ti ara korira: nyún, awọ ara, anafilasisi, iba,
Eto aifọkanbalẹ: orififo, suuru, ailorun, paresthesia, aibalẹ, rudurudu, cramps,
Eto atẹgun: Ikọaláìdúró, ọfun ọfun, kukuru ti ẹmi,
Awọn aati Awọn agbegbe: pẹlu iṣakoso iṣan inu - phlebitis, pẹlu iṣakoso intramuscular - hyperemia ati irora ni aaye abẹrẹ,
Omiiran: asthenia, sweating, vaginitis, peripheral edema, irora ẹhin, leukopenia, neutropenia, ilosoke ninu akoko prothrombin,

Oyun

Lilo Oògùn Kefsepim lakoko oyun le ṣee ṣe nikan ni awọn ọran nibiti awọn anfani ti a pinnu si iya ju ewu ti o pọju si ọmọ inu oyun naa.
Ti o ba wulo, lilo oogun naa lakoko lactation yẹ ki o pinnu lori ifopinsi ọmu.

Ibaraṣepọ pẹlu awọn oogun miiran

Lilo awọn abere to gaju ti aminoglycosides nigbakan pẹlu oogun naa KefsepimO yẹ ki a gba abojuto lati ṣe abojuto iṣẹ kidirin nitori agbara nephrotoxicity ati ototoxicity ti awọn ajẹsara aminoglycoside. A ṣe akiyesi Nephrotoxicity lẹhin lilo nigbakanna ti cephalosporins miiran pẹlu diuretics, bii furosemide. Awọn oogun egboogi-iredodo ti ko ni tairodu, fa fifalẹ imukuro cephalosporins, pọ si eewu. Ifojusi Kefsepim lati 1 si 40 miligiramu / milimita. ni ibamu pẹlu iru awọn parenteral solusan: 0.9% iṣuu soda iṣuu soda fun abẹrẹ, 5% ati 10% awọn iyọda glukosi fun abẹrẹ, 6M iṣuu soda iṣuu soda fun abẹrẹ, glukosi 5% ati iyọda kiloraidi 0.9% fun abẹrẹ, ojutu Ringer pẹlu lactate ati ojutu idapọmọra 5% fun abẹrẹ. Lati yago fun awọn ajọṣepọ oogun ti o ṣeeṣe pẹlu awọn oogun miiran, awọn solusan ti Kefsepim (bii julọ awọn aporo beta-lactam miiran) ko yẹ ki o ṣakoso ni nigbakannaa pẹlu awọn solusan ti metronidazole, vancomycin, gentamicin, tobramycin imi-ọjọ ati imi-ọjọ netilmicin. Ninu ọran ti ipade ti oogun Kefsepim pẹlu awọn oogun wọnyi, o gbọdọ tẹ ogun aporo kọọkan lọtọ.

Fọọmu doseji:

lulú fun ojutu fun iṣọn-ẹjẹ ati iṣakoso iṣan inu iṣan

ninu igo kan ni:

Akọle

Adapo, g

0,5 g

1 g?

Cehydpime hydrochloride monohydrate, iṣiro pẹlu cefepime

(to pH lati 4.0 si 6.0)

lulú lati funfun si funfun funfun.

Iṣe oogun elegbogi

Elegbogi

Akoko Cefepime jẹ aporo apọju-igbohunsafẹfẹ cephalosporin. Cepepime ṣe idiwọ iṣakojọpọ ti awọn ọlọjẹ sẹẹli bakitiki, ni ifahan titobi pupọ ti igbese bactericidal lodi si awọn ọlọjẹ giramu-gram ati awọn alamọ-odi, pẹlu awọn igara pupọ julọ sooro si aminoglycosides tabi awọn egboogi iran cephalosporin kẹta bii ceftazidime.

Cepepime jẹ sooro ga pupọ si hydrolysis ti beta-lactamases pupọ, o ni ifẹkufẹ kekere fun beta-lactamases ati yarayara sinu awọn sẹẹli ti awọn kokoro-aarun odi.

O ti fihan pe cefepime ni affinity giga pupọ fun iru amuye penicillin abuda 3 (PSB), ibaramu giga fun iru 2 PSB, ati ibaramu oniṣedeede fun iru 1a ati 16 PSB. Cepepime ni ipa bakiki lori ọpọlọpọ awọn kokoro arun.

Cepepime n ṣiṣẹ lodi si awọn microorganism wọnyi:

Staphylococcus aureus (pẹlu awọn igara ti o ṣafihan beta-lactamase), Epphyramidis Staphylococcus (pẹlu awọn igara ti n ṣafihan beta-lactamase), awọn igara miiran ti staphylococcus spp. C), pirapupo adagun Streptococcus (pẹlu awọn igara pẹlu iduroṣinṣin dede si penicillin - ifọkansi inhibitory kere julọ jẹ lati 0.1 si 1 μg / milimita), beta-hemolytic Streptococcus spp. (awọn ẹgbẹ C, G, F), boptoptoccus bovis (ẹgbẹ D), Streptococcus spp. awọn ẹgbẹ ti awọn wundia,

Akiyesi: Ọpọlọpọ awọn igara enterococcal, gẹgẹ bi Enterococcus faecalis, ati staphylococci methicillin-sooro jẹ sooro si awọn aakoko-ara ti egboogi cephalosporin, pẹlu akoko-ina.

Acinetobacter calcoaceticus (awọn igara ti anitratus, lwofii),
Aeromonas hydrophila,
Capnocytophaga spp.,.
Citrobacter spp. (pẹlu awọn iyatọ Citrobacter, Citrobacter freundii),
Campylobacter jejuni,
Enterobacter spp. (pẹlu Enterobacter cloacae, Enterobacter aerogenes, Enterobacter tizakii),
Eslikahia coli,
Gardnerella vaginalis,
Haemophilus ducreyi,
Aarun ayọkẹlẹ Haemophilus (pẹlu beta-lactamase ti o ṣẹda awọn igara),
Haemophilus parainfluenzae, Hafnia alvei,
Klebsiella spp. (pẹlu Klebsiella pneumoniae, Klebsiella oxytoca, Klebsiella ozaenae),
Legionella spp.,
Morganella morganii,
Moraxella catarrhalis (Branhamella catarrhalis) (pẹlu awọn igara iṣelọpọ beta-lactamase),
Neisseria gonorrhoeae (pẹlu awọn igara ti o ṣafihan beta-lactamase),
Neisseria meningitidis,
Pantoea agglomerans (eyiti o mọ tẹlẹ bi agglomerans Enterobacter),
Proteus spp. (pẹlu Proteus mirabilis ati Proteus vulgaris),
Providencia spp. (pẹlu Providencia rettgeri, Providencia stuartii),
Pseudomonas spp. (pẹlu Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas stutzer),
Salmonella spp.,
Serratia spp. (pẹlu awọn marcescens Serratia, Serratia liquefaciens),
Shigella spp.,
Yersinia enterocolitica,

Akiyesi: cefepime jẹ aisimi si ọpọlọpọ awọn igara ti Stenotrophomonas maltophilia, eyiti a mọ tẹlẹ bi Xanthomonas maltophilia ati Pseudomonas maltophilia).

Anaerobes:

Bacteroides spp.,.
Cloringidium perfringens,
Fusobacterium spp.,
Mobiluncus spp.,.
Peptostreptococcus spp.,.
Prevotella melaninogenica (ti a mọ bi Bacteroides melaninogenicus),
Veillonella spp.,

Akiyesi: Cepepime jẹ aisimi lodi si Bacteroides fragilis ati Clostridium difficile. Atẹle keji ti awọn microorganisms si cefepime ndagba laiyara.

Elegbogi

Iwọn awọn ifọkansi pilasima ti akoko irọlẹ ni awọn agbalagba ti o ni ilera ni awọn akoko pupọ lẹhin iṣakoso iṣan inu ọkan fun iṣẹju 30 si wakati 12 ati awọn ifọkansi ti o pọju (C_tah) ni a fun ni tabili ni isalẹ.

Iwọn awọn ifọkansi cefepime pilasima (μg / milimita) lẹhin iṣakoso iṣan inu.